Angiotensin II receptor blockers which, unlike ACE inhibitors, don’t prevent angiotensin formation, but rather block it from acting upon the blood vessels by narrowing them.Beta blockers, which block the effects of epinephrine (adrenaline), causing the heart to beat at a slower rate.ACE inhibitors, pills that cause the blood vessels to relax and prevent the release of angiotensin (a hormone that is known for narrowing blood vessels and preventing blood from circulating normally).Renin inhibitors, which are meant to block the production of renin (a kidney enzyme that is linked to an increase in blood pressure).Calcium channel blockers, to prevent calcium buildup in the heart and artery cells.Some of the most common blood pressure meds include: When you have been diagnosed with hypertension at a very advanced stage, or when lifestyle changes aren’t enough to keep your blood pressure under control, doctors will prescribe one or more medications for high blood pressure to get your blood pressure under control as soon as possible. Medication for lowering blood pressure and grapefruit: What do you need to know? Medication prescribed to lower cholesterol levels, specifically statins.Calcium channel blockers or angiotensin inhibitors which are used as high blood pressure treatment.Corticosteroids that are prescribed to treat ulcerative colitis, Crohn’s disease, and many other conditions.Drugs to prevent organ rejection after a transplant.Certain (but not all) anti-anxiety medications, with buspirone being the prime example.Some medications prescribed for arrythmias, such as amiodarone.
Some of the following drugs are known to interact negatively with grapefruit: However, the FDA has required that medical companies specify any potential interactions on their labels, especially for over the counter drugs. What kinds of medication negatively interact with grapefruit? Grapefruit doesn’t interact with just every type of medication out there. This happens because grapefruit juice can also interfere with drug transporters, which are proteins that help our bodies absorb the drugs by moving them to the cells. While the fruit causes some drugs to stay in the body for a longer period of time, it has an opposite effect on some other drugs.įor instance, if you’re taking medication that contains fexofenadine, grapefruit juice will prevent the required amount of drug from entering the blood stream, thus minimizing its efficiency.
There have been a lot of studies conducted on the interaction between grapefruit and medicines. Scientists have discovered that the quantity of CYP3A4 in the body varies from person to person, so the effects of grapefruit juice will also vary from one person to another. Consequently, a drug metabolized with the help of CYP3A4 will stay in your body for longer, in stronger quantities.
Consuming grapefruit, whether the whole fruit, its juice, or any product that contains it, the normal functioning of the CYP3A4 enzyme is blocked, causing a lower metabolization of the drugs. This enzyme helps the body to break down (metabolize) many different kinds of medications. The human body produces an enzyme called CYP3A4, located in the small intestine. When a drug is present in the body in a quantity higher than the recommended dose, it also causes more intense side effects. This poses a risk, as doctors prescribe specific daily doses to meet your medical needs. Grapefruit juice actually indirectly amplifies the effect of many medications.
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